Standard syllabus
Bioorganic chemistry · Graduate · Chemistry
Topics
Peptide and protein chemistry
- Solid-phase peptide synthesis: Fmoc and Boc strategies
- Protecting group chemistry for amino acid side chains
- Native chemical ligation and expressed protein ligation
- Protein folding thermodynamics and kinetics
- Unnatural amino acids and genetic code expansion
- Post-translational modifications: glycosylation, phosphorylation, ubiquitination
- Chemical probes for protein function
- Activity-based protein profiling (ABPP)
- Stapled peptides and peptide mimetics
- Proteomics sample preparation and mass spectrometry
Nucleic acid chemistry
- Phosphoramidite DNA/RNA synthesis
- Modified nucleotides for therapeutics and diagnostics
- CRISPR chemistry: guide RNA and Cas9 mechanism
- Antisense oligonucleotides and siRNA
- DNA damage and repair chemistry
- G-quadruplexes and non-canonical structures
- Click chemistry for nucleic acid labeling
- Ribozymes and deoxyribozymes
- Aptamer selection (SELEX) and applications
- Epigenetic modifications: 5-methylcytosine, hydroxymethylation
Enzyme mechanism and inhibition
- Active site architecture and catalytic residues
- Covalent vs non-covalent enzyme inhibition
- Mechanism-based (suicide) inhibitors
- Transition state analog inhibitors
- Allosteric regulation and cooperativity models
- Cofactor chemistry: PLP, thiamine pyrophosphate, biotin
- Radical SAM enzymes and radical mechanisms
- Metalloenzyme mechanisms: zinc, iron, copper enzymes
- Kinase inhibitors in drug discovery
- Protease inhibitors: HIV protease, caspases
Chemical biology tools
- Bioorthogonal chemistry: click reactions in cells
- Photopharmacology and caged compounds
- Fluorescent probes and biosensors
- Chemogenomics and target identification
- Metabolic labeling and flux analysis
- Glycobiology: glycan synthesis and profiling
- Lipidomics and lipid chemical biology
- Chemical inducers of dimerization
- DNA-encoded libraries for screening
- Ethical considerations in chemical biology research
What each unit includes
Open a unit below for full materials. Typical resources:
- Study guide
- Exam Strategy
- Common Mistakes
- Worksheets
- Word problems
- Mixed Practice
- Multi-Unit Problems
- Review
- Practice test
- Answer key
Study units
Each unit includes a study guide, worksheets, review, practice test, and answer key. One unit is free; subscribe for the full class.
- Peptide and protein chemistry
Solid-phase peptide synthesis: Fmoc and Boc strategies
Coming soon - Nucleic acid chemistry
Phosphoramidite DNA/RNA synthesis
Coming soon - Enzyme mechanism and inhibition
Active site architecture and catalytic residues
Coming soon - Chemical biology tools
Bioorthogonal chemistry: click reactions in cells
Coming soon - Laboratory and research methods
Peptide synthesis and HPLC purification
Coming soon - Applied bioorganic chemistry
Antibody–drug conjugates (ADCs) linker chemistry
Coming soon
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$1,162 · Bioorganic chemistry · 18 tutoring hrs
Study guides, worksheets, reviews, practice tests, and answer keys for 1 class. 18 tutoring hours (1 hr / week · semester). Bundle discount applied vs buying separately. Pay in full via Zelle.