STEM / applied
Medicinal chemistry intro · Undergraduate · Chemistry
Learning objectives from the Medicinal chemistry intro syllabus, grouped by unit. Click an objective for study materials.
Learning objectives
Click an objective for study materials.
Drug discovery process
- History of medicinal chemistry and major drug classes — History of medicinal chemistry and major drug classes
- Drug targets: enzymes, receptors, ion channels, nucleic acids — Drug targets: enzymes, receptors, ion channels, nucleic acids
- Lead discovery: natural products, HTS, fragment-based design — Lead discovery: natural products, HTS, fragment-based design
- Lead optimization: potency, selectivity, ADMET — Lead optimization: potency, selectivity, ADMET
- Structure–activity relationships (SAR) — Structure–activity relationships (SAR)
Physicochemical properties and ADMET
- Lipinski's Rule of Five and drug-likeness — Lipinski's Rule of Five and drug-likeness
- Partition coefficient (log P) and distribution — Partition coefficient (log P) and distribution
- Acid-base properties and pKa of drugs — Acid-base properties and pKa of drugs
- Solubility, permeability, and dissolution — Solubility, permeability, and dissolution
- Absorption, distribution, metabolism, excretion (ADME) — Absorption, distribution, metabolism, excretion (ADME)
Receptor pharmacology and molecular interactions
- Agonists, antagonists, and inverse agonists — Agonists, antagonists, and inverse agonists
- Receptor types: GPCRs, ion channels, nuclear receptors — Receptor types: GPCRs, ion channels, nuclear receptors
- Binding affinity: Ki, IC₅₀, EC₅₀ — Binding affinity: Ki, IC₅₀, EC₅₀
- Enzyme inhibition: competitive, noncompetitive, irreversible — Enzyme inhibition: competitive, noncompetitive, irreversible
- Allosteric modulation — Allosteric modulation
Major drug classes and mechanisms
- Antibiotics: β-lactams, fluoroquinolones, macrolides — Antibiotics: β-lactams, fluoroquinolones, macrolides
- Antiviral agents: nucleoside analogs, protease inhibitors — Antiviral agents: nucleoside analogs, protease inhibitors
- Anticancer drugs: alkylating agents, kinase inhibitors — Anticancer drugs: alkylating agents, kinase inhibitors
- CNS drugs: antidepressants, antipsychotics, anxiolytics — CNS drugs: antidepressants, antipsychotics, anxiolytics
- Cardiovascular drugs: antihypertensives, anticoagulants — Cardiovascular drugs: antihypertensives, anticoagulants
What each unit includes
Open a unit below for full materials. Typical resources:
- Study guide
- Exam Strategy
- Common Mistakes
- Worksheets
- Word problems
- Mixed Practice
- Multi-Unit Problems
- Review
- Practice test
- Answer key
Study units
Each unit includes a study guide, worksheets, review, practice test, and answer key. One unit is free; subscribe for the full class.
- Drug discovery process
History of medicinal chemistry and major drug classes
Coming soon - Physicochemical properties and ADMET
Lipinski's Rule of Five and drug-likeness
Coming soon - Receptor pharmacology and molecular interactions
Agonists, antagonists, and inverse agonists
Coming soon - Major drug classes and mechanisms
Antibiotics: β-lactams, fluoroquinolones, macrolides
Coming soon
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$1,162 · Medicinal chemistry intro · 18 tutoring hrs
Study guides, worksheets, reviews, practice tests, and answer keys for 1 class. 18 tutoring hours (1 hr / week · semester). Bundle discount applied vs buying separately. Pay in full via Zelle.